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Research Advances

Stay Informed About the Latest Oncology Breakthroughs

Explore the forefront of oncological research with our “Research Advances” category. Discover cutting-edge studies, innovative treatments, and scientific insights into cancer. Stay up-to-date with the latest breakthroughs and advancements in the field of oncology to make informed decisions about your health or that of your loved ones. Dive into the world of scientific progress and gain a deeper understanding of how research is shaping the future of cancer care.

The Cellular Soldiers: A Layman’s Guide to Adoptive Living Cell Therapy

The Cellular Soldiers: A Layman’s Guide to Adoptive Living Cell Therapy

Great review article published in the JCO here by Daniel Olson et al. summarizing adoptive cellular therapy for solid tumors and where we are today. I am very excited about solid tumor cellular therapy as we are currently enrolling into solid tumor trials specifically for TIL, PD1 knockout TIL, Neoantigen Selective TIL and TCR MAGE4+ …

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Pioneering Therapies Unveil New Hope for High-Risk Melanoma Patients

Pioneering Therapies Unveil New Hope for High-Risk Melanoma Patients

ASCO 2023 was an incredible conference and I had completely enjoyed the networking, presentations, and evening meetings. Here are two melanoma clinical trials that we had also participated in enrollment at the Orlando Health Cancer Institute. It is incredibly exciting to see patients do better with improved responses as well as improved odds of not …

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A Revolutionary Paradigm Shift to Rectal Cancer Treatment: Insights from the PROSPECT Trial Presented at ASCO 2023

A Revolutionary Paradigm Shift to Rectal Cancer Treatment: Insights from the PROSPECT Trial Presented at ASCO 2023

ASCO 2023 was a ton of fun and lot of learning. In the coming weeks, I’ll share select abstracts that I thought were most important. This article discusses data from a groundbreaking PROSPECT trial which was presented as a Plenary topic at Chicago and published in NEJM last week. Ultimately, this creates more treatment options …

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TILVANCE-301 Phase 3 Trial: Cellular Therapy and Pembrolizumab in Advanced Melanoma

TILVANCE-301 Phase 3 Trial: Cellular Therapy and Pembrolizumab in Advanced Melanoma

Replaying this post as a reminder that this study is enrolling at multiple sites globally. More detailed information can also be seen here at clinicaltrials.gov as well as the sponsor Iovance. All information and data stated in this article are available publicly through online resources that I’ve also linked below for reference. This new trial …

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From Pandemic Response to Cancer Prevention Breakthrough: The Promise of mRNA Vaccine in Malignant Melanoma

From Pandemic Response to Cancer Prevention Breakthrough: The Promise of mRNA Vaccine in Malignant Melanoma

mRNA technology has revolutionized the world of medicine. Known for its role in the creation of COVID-19 vaccines, mRNA has been lauded as a game-changer in the fight against infectious diseases. But mRNA’s impact extends far beyond pandemic control. It’s now making waves in another critical area of healthcare: cancer treatment and prevention.  mRNA stands …

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Adaptimmune: Engineering T-Cell Receptors to Target Cancer Cells Clinical Trial at the Orlando Health Cancer Institute

Adaptimmune: Engineering T-Cell Receptors to Target Cancer Cells Clinical Trial at the Orlando Health Cancer Institute

I am really excited about this new protocol specifically for patients with MAGE4+ HLA restricted SPEAR TILs for Metastatic Melanoma, Non-small Cell Lung Cancer, Head Neck cancer, Ovarian, Endometrial, and Urothelial cancers. The Gastric and Esophageal Cancer cohorts are closed. The social media material seen here was approved both the sponsor and IRB. Please contact …

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A Journey Through the Complex Treatment Landscape of Neuroendocrine Cancers

A Journey Through the Complex Treatment Landscape of Neuroendocrine Cancers

My very first mentor was Dr Larry Kvols who I trained under at the Moffitt Cancer Center during my internal medicine residency. He would tell some good stories on some of the first patients he treated back in the day with a drug no one has ever heard using “octreotide” which today is the main …

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Harnessing ctDNA Testing in the NRG-GI008 Trial: A Personalized Approach to Colon Cancer Treatment

Harnessing ctDNA Testing in the NRG-GI008 Trial: A Personalized Approach to Colon Cancer Treatment

Colon cancer is the third most common cancer worldwide, affecting millions of individuals every year. Currently, the treatment paradigm for resected stage 2 and 3 colon cancer patients typically involves surgery followed by adjuvant chemotherapy to reduce the risk of cancer recurrence. However, the prognosis for these patients varies significantly, with some experiencing a complete …

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Merkel Cell Carcinoma: Shining a Light on the Darkest of Skin Cancers

Merkel Cell Carcinoma: Shining a Light on the Darkest of Skin Cancers

Merkel cell carcinoma (MCC) is the unsung villain of the skin cancer world – rare, aggressive, and often flying under the radar. MCC is a neuroendocrine skin cancer that usually rears its ugly head as a firm, painless nodule on sun-exposed areas of the skin. Risk factors for this sneaky skin invader include advanced age, …

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Navigating Oligometastatic Disease: From Stage IV to Remission, A Personalized Approach to Oligometastatic Cancer Treatment

Navigating Oligometastatic Disease: From Stage IV to Remission, A Personalized Approach to Oligometastatic Cancer Treatment

“How am I doing?”, asked one of my colorectal patients. Ten years ago, I first met John (name changed for privacy), a warm and spirited individual diagnosed with stage 3 colon cancer. After undergoing surgical resection of the primary colon tumor and six months of standard adjuvant chemotherapy with mFOLFOX, John and I optimistically looked …

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Dr. Sajeve Thomas
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  • Home
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    • The essentials
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