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Research Advances

Stay Informed About the Latest Oncology Breakthroughs

Explore the forefront of oncological research with our “Research Advances” category. Discover cutting-edge studies, innovative treatments, and scientific insights into cancer. Stay up-to-date with the latest breakthroughs and advancements in the field of oncology to make informed decisions about your health or that of your loved ones. Dive into the world of scientific progress and gain a deeper understanding of how research is shaping the future of cancer care.

Targeting Urothelial Cancer: EV 103 Study Results

One of the most vivid metaphors for chemotherapy is that of a bomb: it obliterates both good and bad cells, with the hope that only the good ones regenerate. While traditional chemotherapy remains a significant tool in cancer treatment, there’s been a recent shift towards more precise therapies that selectively target cancer cells. In the …

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Shining a Spotlight on Lip Cancer: Understanding and Advocacy

In a recent heartfelt letter to viewers, esteemed news anchor Greg Warmoth bravely opened about his lip cancer diagnosis. This news serves as a reminder of the importance of raising awareness about this particular form of cancer, its typical prognosis, available treatment options, and preventive measures that can be taken. Understanding Lip Cancer: Cutaneous squamous cell cancer is a relatively …

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TVEC: A Promising Solution for Skin-Limited Merkel Cell Carcinoma?

Here’s an interested case of a patient with MCC that I saw this past week. While I’d like to consider systemic immunotherapy with PD1 or dual checkpoint inhibitors, chemotherapy, clinical trial with MDNA or TLR9 agonist/PD1, this patient’s disease was limited to the skin alone. Could we do something different and perhaps with less risk …

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The Critical Interplay: When Oncology Meets Cardiology and Neurosurgery

The Critical Interplay: When Oncology Meets Cardiology and Neurosurgery

Navigating the tumultuous waters of a cancer diagnosis can be a daunting task for any patient. Add to this a significant cardiac issue or a serious neurological complication, and the situation becomes even more intricate. This delicate dance, where life-threatening conditions intersect, highlights the need for truly multidisciplinary care. It’s a timely reminder that medicine …

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Emerging Clinical Trial: Tebentafusp Regimen in Previously Treated Advanced Cutaneous Melanoma

Emerging Clinical Trial: Tebentafusp Regimen in Previously Treated Advanced Cutaneous Melanoma

This is a new clinical trial using Tebentafusp alone or in combination with Pembrolizumab is now open and actively enrolling at the Orlando Health Cancer Institute for patients dealing with Metastatic Cutaneous Melanoma. Tebentafusp is currently FDA approved for all patients with Metastatic Uveal Melanoma. Detailed information can be found here at clinicaltrials.gov and NEJM …

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A Promising New Addition to GIST Treatment Strategies: 2nd line Clinical Trial Open

A Promising New Addition to GIST Treatment Strategies: 2nd line Clinical Trial Open

Article written by one of our Melanoma/Sarcoma Clinical Trial Coordinators Chloe Caldwell to a target audience of healthcare providers regarding a new ongoing protocol for patients dealing with GIST open globally and at the Orlando Health Cancer Institute. All information posted here is publicly available here. Gastrointestinal Stromal Tumors (GIST) constitute a category of soft …

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The Cellular Soldiers: A Layman’s Guide to Adoptive Living Cell Therapy

The Cellular Soldiers: A Layman’s Guide to Adoptive Living Cell Therapy

Great review article published in the JCO here by Daniel Olson et al. summarizing adoptive cellular therapy for solid tumors and where we are today. I am very excited about solid tumor cellular therapy as we are currently enrolling into solid tumor trials specifically for TIL, PD1 knockout TIL, Neoantigen Selective TIL and TCR MAGE4+ …

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Pioneering Therapies Unveil New Hope for High-Risk Melanoma Patients

Pioneering Therapies Unveil New Hope for High-Risk Melanoma Patients

ASCO 2023 was an incredible conference and I had completely enjoyed the networking, presentations, and evening meetings. Here are two melanoma clinical trials that we had also participated in enrollment at the Orlando Health Cancer Institute. It is incredibly exciting to see patients do better with improved responses as well as improved odds of not …

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A Revolutionary Paradigm Shift to Rectal Cancer Treatment: Insights from the PROSPECT Trial Presented at ASCO 2023

A Revolutionary Paradigm Shift to Rectal Cancer Treatment: Insights from the PROSPECT Trial Presented at ASCO 2023

ASCO 2023 was a ton of fun and lot of learning. In the coming weeks, I’ll share select abstracts that I thought were most important. This article discusses data from a groundbreaking PROSPECT trial which was presented as a Plenary topic at Chicago and published in NEJM last week. Ultimately, this creates more treatment options …

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TILVANCE-301 Phase 3 Trial: Cellular Therapy and Pembrolizumab in Advanced Melanoma

TILVANCE-301 Phase 3 Trial: Cellular Therapy and Pembrolizumab in Advanced Melanoma

Replaying this post as a reminder that this study is enrolling at multiple sites globally. More detailed information can also be seen here at clinicaltrials.gov as well as the sponsor Iovance. All information and data stated in this article are available publicly through online resources that I’ve also linked below for reference. This new trial …

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Recent Posts

  • The Call I Keep Getting: What the New Melanoma Individualized Neoantigen Therapy Data Actually Means
  • Third Time’s the Charm
  • When the System Works: A TIL Therapy Story
  • The Next Generation of TIL Therapy Has Arrived — And It Skips the IL-2
  • A Third Chance for RP1: An Option Melanoma Patients Still Need

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Meet the authors

Dr. Sajeve Thomas
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  • Home
  • Blog
    • The essentials
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  • Meet and Greet
    • About Dr Thomas
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  • Ask MedOncMD?
  • 🧠 How I Create My Blog Posts