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Research Advances

Stay Informed About the Latest Oncology Breakthroughs

Explore the forefront of oncological research with our “Research Advances” category. Discover cutting-edge studies, innovative treatments, and scientific insights into cancer. Stay up-to-date with the latest breakthroughs and advancements in the field of oncology to make informed decisions about your health or that of your loved ones. Dive into the world of scientific progress and gain a deeper understanding of how research is shaping the future of cancer care.

Merkel Cell Carcinoma: Shining a Light on the Darkest of Skin Cancers

Merkel Cell Carcinoma: Shining a Light on the Darkest of Skin Cancers

Merkel cell carcinoma (MCC) is the unsung villain of the skin cancer world – rare, aggressive, and often flying under the radar. MCC is a neuroendocrine skin cancer that usually rears its ugly head as a firm, painless nodule on sun-exposed areas of the skin. Risk factors for this sneaky skin invader include advanced age, …

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Navigating Oligometastatic Disease: From Stage IV to Remission, A Personalized Approach to Oligometastatic Cancer Treatment

Navigating Oligometastatic Disease: From Stage IV to Remission, A Personalized Approach to Oligometastatic Cancer Treatment

“How am I doing?”, asked one of my colorectal patients. Ten years ago, I first met John (name changed for privacy), a warm and spirited individual diagnosed with stage 3 colon cancer. After undergoing surgical resection of the primary colon tumor and six months of standard adjuvant chemotherapy with mFOLFOX, John and I optimistically looked …

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New Trial at the Orlando Health Cancer Institute Using Interleukin-2 Superkine (MDNA11) to treat multiple solid tumor types

New Trial at the Orlando Health Cancer Institute Using Interleukin-2 Superkine (MDNA11) to treat multiple solid tumor types

New and exciting immunotherapeutic trial for multiple cancer subtypes. Article written by our senior research coordinator Karin Donaldson. Consider trials earlier in the course in patients with unresectable or metastatic cancer whenever possible. I have sponsor and IRB approval to place this article on this blog! More detail information can be found at MDNA and …

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The Gut Feeling You Can’t Ignore: How H. Pylori and Your Genetics Can Gang Up on You!

The Gut Feeling You Can’t Ignore: How H. Pylori and Your Genetics Can Gang Up on You!  

New article published in the NEJM confirming the high risk for gastric cancer with susceptible folks with H. Pylori infections. Another reason for me to check dna platforms such as 23andme! As a physician who not too long ago discovered my own asymptomatic H. pylori infection, I couldn’t help but wonder if there was more …

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Catching Cancer Before It Spreads: The Promise of ctDNA in Malignant Melanoma

Catching Cancer Before It Spreads: The Promise of ctDNA in Malignant Melanoma

A recent publication by Dr Eroglu et al. in Cancer can be found here! Hope this articles helps! As an oncologist, my days are filled with fascinating and challenging cases, but one recent patient in particular caught my attention. He was a young man who had just undergone surgery to remove high-risk Stage IIC malignant …

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Tackling Tumors with T Cells: Lifileucel’s Revolutionary Approach to Melanoma

Tackling Tumors with T Cells: Lifileucel’s Revolutionary Approach to Melanoma

Iovance recently announced their completion of the BLA to the FDA for Lifeleucel in Metastatic Melanoma. See press release here. Data for this study published in JCO here! This is a treatment protocol that we at the Orlando Health Cancer Institute have been very proud to have enroll and treat melanoma folks as well other …

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Current clinical trial at Orlando Health shows promising results with the use a modified Poliovirus for Melanoma patients

Current clinical trial at Orlando Health shows promising results with the use a modified Poliovirus for Melanoma patients

I have sponsor, regulatory and IRB permissions/approval to post this blog publicly on social media. I am very excited about this protocol using intra-tumoral modified Polio viral therapy for patients with metastatic melanomas. Lerapolturev (formerly known as PVSRIPO) is a type of oncolytic virus that is currently being studied for the treatment of melanoma. An …

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Are We Throwing Out the Baby with the Bathwater? The Case for Upfront Immunotherapy in Locally Advanced Melanoma

Are We Throwing Out the Baby with the Bathwater? The Case for Upfront Immunotherapy in Locally Advanced Melanoma

Melanoma is a tricky disease that often comes back when you least expect it. Just like a sneaky burglar who breaks into your house when you’re not looking, melanoma can hide in your body and then suddenly reappear. That’s exactly what happened to one of my patients, who thought she had beaten the disease years …

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cancer cell

Revolutionizing Cancer Care: Neoantigen Selective TILs at the Orlando Health Cancer Institute Now Enrolling for Breast, Uveal Melanoma, Cutaneous Melanoma, NSCLC, HeadNeck Carcinomas

I have sponsor, regulatory and IRB permissions/approval to post this blog publicly on social media. I am very excited about this protocol using TILs for breast cancer, colorectal, uveal melanomas, and now also inclusive of cutaneous melanoma, nsclc, head/neck carcinoma. Further details can be found here at the sponsor site and at clinical trials.gov. Adoptive …

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ctDNA is a Game-Changer in Cancer Management: Top 5 Reasons I Use ctDNA in Cancer Care

ctDNA is a Game-Changer in Cancer Management: Top 5 Reasons I Use ctDNA in Cancer Care

As an oncologist, I have seen the importance of using circulating tumor DNA (ctDNA) analysis in cancer diagnosis and treatment. ctDNA is a simple blood test that can provide valuable information about a patient’s cancer, making it a valuable tool in the fight against this disease.  Signatera is a technology developed by Natera that uses tumor-informed …

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    • About Dr Thomas
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