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Melanoma

Explore the world of melanoma, a formidable form of skin cancer, through our dedicated “Melanoma” subcategory. Gain valuable insights into the causes, risk factors, and early detection of melanoma. Dive deep into the latest advancements in melanoma treatment options, including surgical interventions, immunotherapy, and targeted therapies. Whether you’re seeking information for prevention, diagnosis, or support, this subcategory is your trusted resource for comprehensive knowledge about melanoma. Together, we’ll navigate this journey toward melanoma awareness and effective management.

Pioneering Therapies Unveil New Hope for High-Risk Melanoma Patients

Pioneering Therapies Unveil New Hope for High-Risk Melanoma Patients

ASCO 2023 was an incredible conference and I had completely enjoyed the networking, presentations, and evening meetings. Here are two melanoma clinical trials that we had also participated in enrollment at the Orlando Health Cancer Institute. It is incredibly exciting to see patients do better with improved responses as well as improved odds of not …

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TILVANCE-301 Phase 3 Trial: Cellular Therapy and Pembrolizumab in Advanced Melanoma

TILVANCE-301 Phase 3 Trial: Cellular Therapy and Pembrolizumab in Advanced Melanoma

Replaying this post as a reminder that this study is enrolling at multiple sites globally. More detailed information can also be seen here at clinicaltrials.gov as well as the sponsor Iovance. All information and data stated in this article are available publicly through online resources that I’ve also linked below for reference. This new trial …

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From Pandemic Response to Cancer Prevention Breakthrough: The Promise of mRNA Vaccine in Malignant Melanoma

From Pandemic Response to Cancer Prevention Breakthrough: The Promise of mRNA Vaccine in Malignant Melanoma

mRNA technology has revolutionized the world of medicine. Known for its role in the creation of COVID-19 vaccines, mRNA has been lauded as a game-changer in the fight against infectious diseases. But mRNA’s impact extends far beyond pandemic control. It’s now making waves in another critical area of healthcare: cancer treatment and prevention.  mRNA stands …

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Adaptimmune: Engineering T-Cell Receptors to Target Cancer Cells Clinical Trial at the Orlando Health Cancer Institute

Adaptimmune: Engineering T-Cell Receptors to Target Cancer Cells Clinical Trial at the Orlando Health Cancer Institute

I am really excited about this new protocol specifically for patients with MAGE4+ HLA restricted SPEAR TILs for Metastatic Melanoma, Non-small Cell Lung Cancer, Head Neck cancer, Ovarian, Endometrial, and Urothelial cancers. The Gastric and Esophageal Cancer cohorts are closed. The social media material seen here was approved both the sponsor and IRB. Please contact …

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Navigating the Complexities of Cancer Care: The Navigator’s Role

Navigating the Complexities of Cancer Care: The Navigator’s Role

This post was written by our melanoma/sarcoma nurse navigator Ashlee Jones. She is highly respected by all members of my team to include the nurses, pharmacist, staff, research team, and physicians! I’ve always felt that new patients diagnosed with cancer can initially have a rough start in the journey given the new diagnosis, the array …

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Catching Cancer Before It Spreads: The Promise of ctDNA in Malignant Melanoma

Catching Cancer Before It Spreads: The Promise of ctDNA in Malignant Melanoma

A recent publication by Dr Eroglu et al. in Cancer can be found here! Hope this articles helps! As an oncologist, my days are filled with fascinating and challenging cases, but one recent patient in particular caught my attention. He was a young man who had just undergone surgery to remove high-risk Stage IIC malignant …

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Tackling Tumors with T Cells: Lifileucel’s Revolutionary Approach to Melanoma

Tackling Tumors with T Cells: Lifileucel’s Revolutionary Approach to Melanoma

Iovance recently announced their completion of the BLA to the FDA for Lifeleucel in Metastatic Melanoma. See press release here. Data for this study published in JCO here! This is a treatment protocol that we at the Orlando Health Cancer Institute have been very proud to have enroll and treat melanoma folks as well other …

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Current clinical trial at Orlando Health shows promising results with the use a modified Poliovirus for Melanoma patients

Current clinical trial at Orlando Health shows promising results with the use a modified Poliovirus for Melanoma patients

I have sponsor, regulatory and IRB permissions/approval to post this blog publicly on social media. I am very excited about this protocol using intra-tumoral modified Polio viral therapy for patients with metastatic melanomas. Lerapolturev (formerly known as PVSRIPO) is a type of oncolytic virus that is currently being studied for the treatment of melanoma. An …

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Are We Throwing Out the Baby with the Bathwater? The Case for Upfront Immunotherapy in Locally Advanced Melanoma

Are We Throwing Out the Baby with the Bathwater? The Case for Upfront Immunotherapy in Locally Advanced Melanoma

Melanoma is a tricky disease that often comes back when you least expect it. Just like a sneaky burglar who breaks into your house when you’re not looking, melanoma can hide in your body and then suddenly reappear. That’s exactly what happened to one of my patients, who thought she had beaten the disease years …

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cancer cell

Revolutionizing Cancer Care: Neoantigen Selective TILs at the Orlando Health Cancer Institute Now Enrolling for Breast, Uveal Melanoma, Cutaneous Melanoma, NSCLC, HeadNeck Carcinomas

I have sponsor, regulatory and IRB permissions/approval to post this blog publicly on social media. I am very excited about this protocol using TILs for breast cancer, colorectal, uveal melanomas, and now also inclusive of cutaneous melanoma, nsclc, head/neck carcinoma. Further details can be found here at the sponsor site and at clinical trials.gov. Adoptive …

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Recent Posts

  • The mRNA moment in melanoma: a 5-year update—and a flashback to the COVID era
  • Emerging Data in Intratumoral Immunotherapy: Replimmune’s RP1 + Nivolumab in Non‑Melanoma Skin Cancers and Acral Melanoma
  • 12 Things I Learned in My First 6 Weeks at AdventHealth
  • 2025 Reflections and 2026 Aspirations: A Medical Oncologist’s Journey in Clinical Excellence, Innovation, and Intentional Living
  • What I’m Most Thankful For This Thanksgiving Weekend

Categories

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Meet the authors

Dr. Sajeve Thomas
Dr Daniel Landau


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  • Home
  • Blog
    • The essentials
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  • Meet and Greet
    • About Dr Thomas
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  • Ask MedOncMD?
  • 🧠 How I Create My Blog Posts