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Melanoma

Explore the world of melanoma, a formidable form of skin cancer, through our dedicated “Melanoma” subcategory. Gain valuable insights into the causes, risk factors, and early detection of melanoma. Dive deep into the latest advancements in melanoma treatment options, including surgical interventions, immunotherapy, and targeted therapies. Whether you’re seeking information for prevention, diagnosis, or support, this subcategory is your trusted resource for comprehensive knowledge about melanoma. Together, we’ll navigate this journey toward melanoma awareness and effective management.

Exciting Advances in Frontline Treatment for Metastatic Melanoma from ASCO 2024

The American Society of Clinical Oncology (ASCO) 2024 conference was a remarkable event, bringing together leading minds in oncology to discuss the latest breakthroughs and research in cancer treatment. This year’s conference was particularly notable for the innovative approaches presented in the treatment of metastatic melanoma, a challenging and aggressive form of skin cancer. In …

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The Hope of a New Sunrise

Navigating the unpredictable waves of cancer treatment with our patients is not just a professional journey but a deeply personal experience that binds us together in shared hope and resilience. This week, I found myself reflecting on the incredible journey of a young 40 year old patient I’ve been caring for over the past six …

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Innovative Therapy for a Rare Cancer: Lifileucel’s Impact on Mucosal Melanoma

Last week, we heard the tremendous news regarding the FDA approval of Lifileucel for metastatic melanoma refractory to prior immunotherapy checkpoint inhibitor therapy. In this article, let’s focus on an uncommon melanoma subtype in the general population that we routinely see in practice. In the realm of oncology, the fight against cancer continually evolves, marked …

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Lifileucel (Amtagvi): A New Horizon in Metastatic Melanoma Treatment

On February 16th 2024, after a roughly 2-3 year wait fully aware of the data and the patient beneficial long term outcomes in a subset of patients, the FDA finally announced the approval of the first cellular therapy approved for solid tumors and specifically TIL in treatment refractory malignant melanoma. TIL using Amtagvi (Lifileucel) is …

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OBX-115: The Next Big Leap in Tumor-Infiltrating Lymphocyte Therapy

This is a new modified TIL protocol developed by Obsidian Therapeutics now open for enrollment at the Orlando Health Cancer Institute. All information provided here are from public sources and the protocol details can be found here. Please reach out to Karin Donaldson if interest in seeking this trial. This current protocol is specific for …

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Cellular Therapy Trial: A Step Forward in Precision Oncology Targeting MAGE-A1, HPV16, and PRAME

I am very excited to announce the opening of a new Cellular Therapy by Tscan Therapeutics using TCR protocol at the Orlando Health Cancer Institute (OHCI) targeting Melanoma, Head/Neck Cancer, NSCLC, Ovarian, and HPV positive Anal-Cervical SCC. Information for this new open clinical trial was provided from a public source. Please reach out to Karin …

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Echoes of Victory: The Significance of Ringing the Bell into Cancer Remission

Embarking on the tumultuous journey that is stage IV melanoma, both patients and healthcare providers often find themselves in an intricate dance of vulnerability, resilience, and human connection. This is the poignant tale of a young man’s persistent battle against melanoma, his remarkable perseverance through a myriad of treatments, and the eventual moment of triumph …

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The Promising Intersection of Fecal Microbiota Transplantation and Cancer Immunotherapy: An Emerging Frontier for Refractory Melanoma Treatment

This post is based on the interesting results published by Routy et al. Nature July 2023. I am hoping that we will soon open a protocol using FMT in cancer patients and I will announce once we’re site activated at the Orlando Health Cancer Institute. The revolutionary world of cancer treatment is once again on …

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Uveal melanoma, a rare and aggressive form of eye cancer, has just witnessed a groundbreaking development in its treatment landscape. The Food and Drug Administration (FDA) recently granted approval to the HEPZATO KIT, an innovative liver-directed therapy that offers new hope to adult patients with uveal melanoma and unresectable hepatic metastases.

A Breakthrough in Uveal Melanoma Treatment: HEPZATO KIT

Uveal melanoma, a rare and aggressive form of eye cancer, has just witnessed a groundbreaking development in its treatment landscape. The Food and Drug Administration (FDA) recently granted approval to the HEPZATO KIT, an innovative liver-directed therapy that offers new hope to adult patients with uveal melanoma and unresectable hepatic metastases.

Emerging Clinical Trial: Tebentafusp Regimen in Previously Treated Advanced Cutaneous Melanoma

Emerging Clinical Trial: Tebentafusp Regimen in Previously Treated Advanced Cutaneous Melanoma

This is a new clinical trial using Tebentafusp alone or in combination with Pembrolizumab is now open and actively enrolling at the Orlando Health Cancer Institute for patients dealing with Metastatic Cutaneous Melanoma. Tebentafusp is currently FDA approved for all patients with Metastatic Uveal Melanoma. Detailed information can be found here at clinicaltrials.gov and NEJM …

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Recent Posts

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  • Emerging Data in Intratumoral Immunotherapy: Replimmune’s RP1 + Nivolumab in Non‑Melanoma Skin Cancers and Acral Melanoma
  • 12 Things I Learned in My First 6 Weeks at AdventHealth
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  • What I’m Most Thankful For This Thanksgiving Weekend

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Dr. Sajeve Thomas
Dr Daniel Landau


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  • Home
  • Blog
    • The essentials
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    • About Dr Thomas
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  • 🧠 How I Create My Blog Posts