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Immunotherapy

Unleash the power of your body’s immune system in the fight against cancer with our “Immunotherapy” subcategory. Delve into the realm of groundbreaking treatments that empower your immune system to recognize and combat cancer cells. Explore the latest advances in immunotherapy, from checkpoint inhibitors to CAR-T cell therapies, and learn how they are revolutionizing the landscape of cancer treatment. Join us on a journey to understand how harnessing your body’s natural defenses is paving the way for more targeted and effective therapies in the fight against cancer.

TVEC: A Promising Solution for Skin-Limited Merkel Cell Carcinoma?

Here’s an interested case of a patient with MCC that I saw this past week. While I’d like to consider systemic immunotherapy with PD1 or dual checkpoint inhibitors, chemotherapy, clinical trial with MDNA or TLR9 agonist/PD1, this patient’s disease was limited to the skin alone. Could we do something different and perhaps with less risk …

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The Cellular Soldiers: A Layman’s Guide to Adoptive Living Cell Therapy

The Cellular Soldiers: A Layman’s Guide to Adoptive Living Cell Therapy

Great review article published in the JCO here by Daniel Olson et al. summarizing adoptive cellular therapy for solid tumors and where we are today. I am very excited about solid tumor cellular therapy as we are currently enrolling into solid tumor trials specifically for TIL, PD1 knockout TIL, Neoantigen Selective TIL and TCR MAGE4+ …

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TILVANCE-301 Phase 3 Trial: Cellular Therapy and Pembrolizumab in Advanced Melanoma

TILVANCE-301 Phase 3 Trial: Cellular Therapy and Pembrolizumab in Advanced Melanoma

Replaying this post as a reminder that this study is enrolling at multiple sites globally. More detailed information can also be seen here at clinicaltrials.gov as well as the sponsor Iovance. All information and data stated in this article are available publicly through online resources that I’ve also linked below for reference. This new trial …

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From Pandemic Response to Cancer Prevention Breakthrough: The Promise of mRNA Vaccine in Malignant Melanoma

From Pandemic Response to Cancer Prevention Breakthrough: The Promise of mRNA Vaccine in Malignant Melanoma

mRNA technology has revolutionized the world of medicine. Known for its role in the creation of COVID-19 vaccines, mRNA has been lauded as a game-changer in the fight against infectious diseases. But mRNA’s impact extends far beyond pandemic control. It’s now making waves in another critical area of healthcare: cancer treatment and prevention.  mRNA stands …

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Adaptimmune: Engineering T-Cell Receptors to Target Cancer Cells Clinical Trial at the Orlando Health Cancer Institute

Adaptimmune: Engineering T-Cell Receptors to Target Cancer Cells Clinical Trial at the Orlando Health Cancer Institute

I am really excited about this new protocol specifically for patients with MAGE4+ HLA restricted SPEAR TILs for Metastatic Melanoma, Non-small Cell Lung Cancer, Head Neck cancer, Ovarian, Endometrial, and Urothelial cancers. The Gastric and Esophageal Cancer cohorts are closed. The social media material seen here was approved both the sponsor and IRB. Please contact …

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Are We Throwing Out the Baby with the Bathwater? The Case for Upfront Immunotherapy in Locally Advanced Melanoma

Are We Throwing Out the Baby with the Bathwater? The Case for Upfront Immunotherapy in Locally Advanced Melanoma

Melanoma is a tricky disease that often comes back when you least expect it. Just like a sneaky burglar who breaks into your house when you’re not looking, melanoma can hide in your body and then suddenly reappear. That’s exactly what happened to one of my patients, who thought she had beaten the disease years …

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cancer cell

Revolutionizing Cancer Care: Neoantigen Selective TILs at the Orlando Health Cancer Institute Now Enrolling for Breast, Uveal Melanoma, Cutaneous Melanoma, NSCLC, HeadNeck Carcinomas

I have sponsor, regulatory and IRB permissions/approval to post this blog publicly on social media. I am very excited about this protocol using TILs for breast cancer, colorectal, uveal melanomas, and now also inclusive of cutaneous melanoma, nsclc, head/neck carcinoma. Further details can be found here at the sponsor site and at clinical trials.gov. Adoptive …

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ctDNA is a Game-Changer in Cancer Management: Top 5 Reasons I Use ctDNA in Cancer Care

ctDNA is a Game-Changer in Cancer Management: Top 5 Reasons I Use ctDNA in Cancer Care

As an oncologist, I have seen the importance of using circulating tumor DNA (ctDNA) analysis in cancer diagnosis and treatment. ctDNA is a simple blood test that can provide valuable information about a patient’s cancer, making it a valuable tool in the fight against this disease.  Signatera is a technology developed by Natera that uses tumor-informed …

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close up photo of person holding syringe

A New Way to Tackle Cancer: Understanding Intratumoral Therapy

Imagine if your body had superpowers to fight cancer! Well, that’s exactly what a new treatment called Intratumoral therapy does. By giving your body the tools it needs to attack cancer cells, this treatment is changing the game for patients with unresectable or metastatic melanoma. Some of the treatments are directly killing cancer cells itself …

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Revolutionizing the Treatment of Mismatch Repair-Deficient Locally Advanced Rectal Cancer: The Promise of Checkpoint Inhibitors

Revolutionizing the Treatment of Mismatch Repair-Deficient Locally Advanced Rectal Cancer: The Promise of Checkpoint Inhibitors

As a physician, one of the most challenging types of cancer to treat is locally advanced rectal cancer. These tumors have often grown to the point where surgery alone is not enough to remove all of the cancer and prevent recurrence. That’s why the standard of care for these patients is a treatment approach called …

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Recent Posts

  • The mRNA moment in melanoma: a 5-year update—and a flashback to the COVID era
  • Emerging Data in Intratumoral Immunotherapy: Replimmune’s RP1 + Nivolumab in Non‑Melanoma Skin Cancers and Acral Melanoma
  • 12 Things I Learned in My First 6 Weeks at AdventHealth
  • 2025 Reflections and 2026 Aspirations: A Medical Oncologist’s Journey in Clinical Excellence, Innovation, and Intentional Living
  • What I’m Most Thankful For This Thanksgiving Weekend

Categories

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    • Biliary tract cancer (3)
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    • Melanoma (34)
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Meet the authors

Dr. Sajeve Thomas
Dr Daniel Landau


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  • Home
  • Blog
    • The essentials
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  • Meet and Greet
    • About Dr Thomas
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  • Ask MedOncMD?
  • 🧠 How I Create My Blog Posts