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Extending Survival in Kidney Cancer: The Promise of Immunotherapy to Prevent Recurrences

New article published in NEJM demonstrated activity of Pembrolizumab adjuvantly given for resected intermediate, poor risk and resected metastatic RCC. Kidney cancer remains a significant health challenge worldwide, with renal-cell carcinoma (RCC) being the most common type. Traditionally, surgery has been the primary treatment for localized kidney cancer, but the risk of recurrence remains high. …

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The Hope of a New Sunrise

Navigating the unpredictable waves of cancer treatment with our patients is not just a professional journey but a deeply personal experience that binds us together in shared hope and resilience. This week, I found myself reflecting on the incredible journey of a young 40 year old patient I’ve been caring for over the past six …

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A Case Study of Clear Cell Sarcoma Masquerading as Melanoma

In the intricate world of oncology, diagnosing and treating cancer presents myriad challenges, particularly when patients exhibit rare or atypical manifestations of the disease. A compelling example of this complexity recently unfolded with a young patient from the Caribbean who presented with a large, painful scalp mass. Initially diagnosed as locally advanced skin cancer, subsequent …

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Navigating a Cervical Cancer Diagnosis: A Personal Journey to Comprehensive Care

I do not personally treat cervical cancers however I do have a good understanding of these disease types mainly for the purposes of rounding on the teaching inpatient oncology service where I could potentially see any solid tumor malignancy and occasionally I am called on from family members with cousins or friends that were recently …

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The Potential of Alectinib in Resected Non-Small Cell Lung Cancer: Insights from the ALINA Study

New exciting data published in the NEJM demonstrating improved for a specific subset of lung cancer patients but also demonstrating the power of targeted therapies when we can identify a driver mutation that is sensitive or “actionable” with a treatment to shut down its specific function. Exciting! Non-Small Cell Lung Cancer (NSCLC) represents a significant …

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Breathing Through Barriers: A Patient’s Guide to Overcoming SVC Syndrome

I’m currently on the inpatient medical oncology service. As an attending, we each take turns each month taking all oncology consults for the downtown hospital center. There was an interesting patient our team saw this past week who presented with a new diagnosis of Stage IV NSCLC and SVC syndrome. A 52-year-old woman who, amidst …

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From Hope to Caution: The Complex Landscape of CAR-T Therapy and Ultra-Small Risk for T-Cell Lymphomas

The medical community continues to explore groundbreaking treatments in the fight against cancer, with CAR-T therapy standing out for its innovative approach. This treatment, involving the genetic modification of a patient’s T cells to target cancer cells, has provided new avenues for those battling certain blood cancers. Here, we delve into the essence of CAR-T …

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Innovative Therapy for a Rare Cancer: Lifileucel’s Impact on Mucosal Melanoma

Last week, we heard the tremendous news regarding the FDA approval of Lifileucel for metastatic melanoma refractory to prior immunotherapy checkpoint inhibitor therapy. In this article, let’s focus on an uncommon melanoma subtype in the general population that we routinely see in practice. In the realm of oncology, the fight against cancer continually evolves, marked …

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Lifileucel (Amtagvi): A New Horizon in Metastatic Melanoma Treatment

On February 16th 2024, after a roughly 2-3 year wait fully aware of the data and the patient beneficial long term outcomes in a subset of patients, the FDA finally announced the approval of the first cellular therapy approved for solid tumors and specifically TIL in treatment refractory malignant melanoma. TIL using Amtagvi (Lifileucel) is …

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Deciphering the Complexities of Cancer Diagnosis and Treatment

The recent news of King Charles’s cancer diagnosis, post his treatment for an enlarged prostate, has brought to the forefront the intricate process of cancer diagnosis and treatment. This case underscores the critical importance of understanding cancer’s specific type and stage, which are pivotal in determining the most appropriate treatment strategy and prognosis. This guide …

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